SAIKOGENIN A

Name	saikogenin A
Synonyms	saikogenin A Clinopodiside A1 Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-
CAS	5092-09-1

Molecular Formula	C30H48O4
Molar Mass	472.7
Density	1.16±0.1 g/cm3(Predicted)
Melting Point	287-293 °C
Boling Point	607.4±55.0 °C(Predicted)
Solubility	Insuluble (9.0E-4 g/L) (25 °C)
Appearance	White powder
pKa	14.47±0.70(Predicted)
Storage Condition	2-8°C
MDL	MFCD00238674
In vitro study	Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.
In vivo study	Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.

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